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Plateletapheresis program. II. Computer selection of HLA compatible donors
Author(s) -
Jorgensen DW,
McFarland JG,
Hillman RS,
Slichter SJ
Publication year - 1984
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1984.24484275566.x
Subject(s) - donation , medicine , human leukocyte antigen , blood donor , selection (genetic algorithm) , matching (statistics) , immunology , population , platelet , intensive care medicine , antigen , computer science , environmental health , pathology , artificial intelligence , economics , economic growth
A rapid, cost‐effective data entry and computerized matching system was developed for selection of HLA compatible cytapheresis donors for platelet‐alloimmunized patients. The system was user‐orientated with a computer‐generated prompting system that facilitated program operation. Expansion of the number of compatible donors was achieved by treating splits and crossreactive HLA antigens as identical. By this mechanism, a 500‐member donor pool easily supported the needs of a large patient population for single‐donor cytapheresis platelets. An average of 3.4 compatible donors per patient was identified. For only two of the 48 (4%) thrombocytopenic recipients was transfusion support from the available donors inadequate to provide a posttransfusion platelet increment. At the end of 7 months, donation frequency for the 441 donors then in the pool averaged 2.0 +/− 2.4. This figure increased to 2.8 +/− 2.4 donations for the 176 panel members who actually underwent cytapheresis. Thus, the impact on donors participating in this program was not excessive.