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Immunological characteristics and clinical significance of anti‐H in the Ah phenotype
Author(s) -
Whitsett C.F.,
Cobb M.,
Pierce J.A.,
Parvin M.
Publication year - 1984
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1984.24284173350.x
Subject(s) - phenotype , immunology , red cell , medicine , coombs test , microbiology and biotechnology , andrology , biology , chemistry , antibody , genetics , gene
A red cell survival study with 51Chromium‐labeled A1 cells was performed in a patient with the Ah phenotype whose serum contained IgM anti‐H but not anti‐A1. A1 cells were agglutinated weakly at 37 degrees C in the crossmatch, but not in the antiglobulin test. One hour after the survival study was begun, 67 percent of injected cells had been destroyed, and only 20 percent of the labeled cells remained after 24 hours. This study suggests that Ah individuals should be transfused only with Ah or Oh red cells.