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Effect of cardiopulmonary bypass on plasma fibronectin, IgG, and C3
Author(s) -
Gandhi J. G.,
Salm T. Vander,
Szymanski I. O.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23684074266.x
Subject(s) - fibronectin , cardiopulmonary bypass , chemistry , plasma concentration , medicine , endocrinology , biochemistry , extracellular matrix
The effect of cardiopulmonary bypass operations on the concentration of plasma fibronectin, IgG, and C3 was studied in 28 patients. During cardiopulmonary bypass operations, plasma IgG, and C3 decreased to about 45 percent of their preoperative concentrations, probably as a result of hemodilution and blood loss. On the average, plasma fibronectin decreased significantly more (p < 0.002), to 32 percent of its preoperative concentration, probably as a result of hemodilution, blood loss, and consumption. We assumed that consumption of fibronectin occurred when its concentration decreased more than the concentrations of IgG and C3. Interestingly, consumption of fibronectin during bypass operations was not demonstrated in seven of the 28 patients who did not require blood products within the 24‐hour period after operation. We suggest that consumption, rather than dilution, of plasma fibronectin might be clinically important. A significant (p < 0.002) negative correlation was observed between the length of the bypass and the concentration of plasma fibronectin during this 24‐hour period. We also studied the rate of regeneration of fibronectin, IgG, and C3 in 12 of these patients. The concentrations of fibronectin and C3 were normal by the fifth postoperative day. The rate of regeneration of IgG, however, was slower than that of fibronectin and C3.