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Red cell sensitization due to anti‐D in anti‐lymphocyte globulin
Author(s) -
Shirey R.S.,
Smith B.,
Sensenbrenner L.,
Bauer T.W.,
Ness P.M.,
Kickler T.S.,
Gibble J.W.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23584018718.x
Subject(s) - sensitization , aplastic anemia , globulin , immunology , lymphocyte , red cell , antibody , medicine , anemia , bone marrow
Four Rh‐positive patients with severe aplastic anemia received equine anti‐lymphocyte globulin. Each developed a positive direct antiglobulin test. Anti‐D was identified in eluates prepared from the patients' sensitized red cells. The administered lot of anti‐lymphocyte globulin was found to contain anti‐D. Red cell sensitization due to passively acquired Rh antibodies can result from the administration of anti‐lymphocyte globulin.