Studies on the blood of an MsHe/MS u proposita and her family

The serum of a black woman has been found to contain a potent alloanti‐N that reacted in direct agglutination tests with the ‘N’ antigen carried on Ss‐active sialoglycoprotein. Thus far, such antibodies have been observed only in the sera of MS u / MS u individuals. However, our proposita had red cells that lacked ‘N’. Her blood type was M+, N−, S−, s+, U+, He+. Results of family studies indicate that she is of the genotype MsHe/MS u . Our findings are consistent with recently reported data on the structure of the Henshaw antigen, which is located on a Ss‐active sialoglycoprotein that does not carry ‘N’.