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Auto‐anti‐A 1 antibody in a patient with metastatic adenocarcinoma
Author(s) -
Castella A.,
LaBarge B. P.,
Lauenstein K. J.,
Davey F. R.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23483276872.x
Subject(s) - antibody , medicine , dithiothreitol , autoantibody , anemia , adenocarcinoma , immunology , chemistry , cancer , biochemistry , enzyme
An autoantibody was found on the red cells of a patient who had never been transfused previously, but was ill with metastatic adenocarcinoma. The patient's blood group was A t . In addition, the patient's serum and the eluate from the patient's red cells agglutinated A, but not A 2 , B, and O red cells. This auto‐A, antibody was reactive at a wide thermal range and was inactivated by dithiothreitol, suggesting the presence of an IgM immunoglobulin. Moreover, the antibody was not associated with a hemolytic anemia.