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Microaggregate blood filtration and the febrile transfusion reaction
Author(s) -
Wenz B.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23283172868.x
Subject(s) - filtration (mathematics) , centrifugation , medicine , chromatography , blood transfusion , filter (signal processing) , anesthesia , surgery , chemistry , mathematics , computer science , statistics , computer vision
Seventy‐four patients with chronic transfusion requirements and histories of repetitive febrile reactions were transfused with 1138 units of microaggregate‐filtered red cells. The filtered blood was prepared using either a direct interception or a depth filter. One‐half of the units were centrifuged immediately prior to filtration. Microaggregate filtration reduced the overall incidence of febrile transfusion reactions by 77 percent. The centrifugation‐filtration protocol reduced the rate of reactions by 98 percent. There were no differences between the ability of the different filters to reduce the reaction rate; however, red cell loss was twice as large with the depth filter as with the direct interception filter. The numerical criterion for “leukocyte‐poor blood” was met in all units processed by centrifugation‐filtration. Only units processed during the last 2 weeks of shelf‐life fulfilled this criterion when centrifugation was omitted from the procedure. The majority of the latter units were clinically tolerated well due to their reduced granulocyte content.