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Fatal hemolytic disease of a newborn due to anti‐D in an Rh‐positive D u variant mother *
Author(s) -
Lacey P. A.,
Caskey C. R.,
Werner D. J.,
Moulds J. J.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23283172867.x
Subject(s) - hemolytic disease of the newborn (abo) , amniocentesis , hydrops fetalis , medicine , rh blood group system , erythroblastosis fetalis , fetus , pregnancy , obstetrics , titer , autopsy , disease , pediatrics , prenatal diagnosis , immunology , antibody , biology , genetics
This report presents an account of fatal hemolytic disease of the newborn (HDN) due to anti‐D in a mother whose red cells showed the phenotypic characteristics of Rh positive D u variant. The proposita's third pregnancy was uneventful until the eighth month, when she presented with an unusually large abdomen. A sonogram showed fetal hydrops, and amniocentesis yielded a Δ OD 450 reading in Zone 3. Anti‐D with a titer of 4096 was identified in the mother's serum. Following delivery by cesarean section, the premature infant did not respond to resuscitation. The autopsy findings were consistent with Rh erythroblastosis fetalis. The proposita has been classified as a Category VI D u variant with anti‐D in her serum.