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Survival of MM red cells during hypothermia in two patients with anti‐M
Author(s) -
Kurtz S. R.,
Ouellet R.,
McMican A.,
Valeri C. R.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23183147302.x
Subject(s) - hypothermia , antibody , titer , medicine , in vivo , red blood cell , in vitro , red cell , immunology , andrology , gastroenterology , chemistry , biology , biochemistry , microbiology and biotechnology
The in vivo survival of M(M+N—) red cells in two patients with anti‐M was studied during hypothermia. The antibodies were IgM, of low titer, and did not react at 30°C. 51 Cr survival studies were performed using 2 ml of labeled blood. There was normal circulation of M(M+N—) cells at 37°C and no accelerated loss of these cells at blood temperatures between 16 and 28°C. One patient received 187 ml of MN (M+N+) red cells when the blood temperature was 25°C without evidence of clinical transfusion reactions and without development of positive direct anti‐human globulin test. Hypothermia did not adversely affect the immediate survival of M(M+N—) red cells transfused to patients with anti‐M antibodies reactive in vitro below 30°C