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Use of whole blood exchange transfusion to supply neutrophils to septic, neutropenic neonates
Author(s) -
Christensen R.D.,
Anstall H.B.,
Rothstein G.
Publication year - 1982
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1982.22683068613.x
Subject(s) - neutropenia , sepsis , medicine , blood transfusion , whole blood , exchange transfusion , granulocyte , leukopenia , neonatal sepsis , absolute neutrophil count , anesthesia , immunology , chemotherapy
When neutropenia due to exhaustion of the marrow neutrophil reserve, develops in a neonate with bacterial sepsis the likelihood of survival is very small. We report such a case who was treated with a double‐ volume exchange transfusion using fresh unstored whole blood. We were able to determine a net gain of 5 × 10(8) neutrophils per kg. Then, in neutropenic neonatal animals, neutrophil transfusion by double‐volume exchange transfusion with unstored blood was investigated.