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Storage and survival of red blood cells with elevated sodium levels
Author(s) -
Wallas C.H.,
Harris A.S.,
Wetherall N.T.
Publication year - 1982
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1982.22583017459.x
Subject(s) - red blood cell , sodium , chemistry , red cell , phosphate , lactate dehydrogenase , intracellular , white blood cell , andrology , medicine , biochemistry , enzyme , organic chemistry
Approximately 25 percent of black blood donors have an elevated red blood cell (RBC) sodium (Nai) level compared with white donors. This elevation results in a significant increase in the mean Nai from black (9.00 ± 2.96 mmoles/l RBC) as compared to white blood donors (7.04 ± 1.48 mmoles/l RBC, p less than 0.001). Red blood cells from four black donors with mean Nai levels of 15 ± 2.8 mmoles/l RBC were stored for 35 days in citrate‐phosphate‐dextrose‐adenine and compared to that of four donors with normal levels of Nai. Serial measurements of red blood cell adenosine triphosphate, diphosphoglycerate, glucose‐6‐phosphate dehydrogenase, pyruvic kinase, lactate production rates, and intracellular cations showed no differences between the two donor groups. Furthermore, the mean 24‐hour posttransfusion survival was not significantly different for the high Nai group (83.2 ± 5.6%) as compared with the control group (82.3 ± 6.9%). Based on this study, it is not necessary to eliminate individuals with an elevated red blood cell Nai level as blood donors.