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Selection of compatible kidney donors for recipients with multiple cytotoxic antibodies
Author(s) -
Larsen A. E.
Publication year - 1982
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1982.22482251218.x
Subject(s) - cytotoxic t cell , antibody , human leukocyte antigen , medicine , immunology , kidney transplantation , antigen , transplantation , kidney , isoantibodies , histocompatibility testing , panel reactive antibody , in vitro , biology , biochemistry
Cytoxic antibodies developed in 33 (14.6%) of 226 renal transplant candidates while awaiting transplantation. Antibody formation was not associated with primary kidney disease, nor was the frequency of antibody formation increased following deliberate transfusion. Analysis of the HLA types of panel cells against which cytotoxic sera failed to react predicted donor kidney antigens which would be acceptable to the recipient. Crossmatching with all stored, reactive serum samples as well as a current sample, is imperative.