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An antibody that recognizes a determinant common to S and s‐bearing sialoglycoproteins
Author(s) -
Issitt P. D.,
Wilkinson S. L.,
Tregellas W. M.,
Lee C.
Publication year - 1982
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1982.22382224935.x
Subject(s) - sialoglycoproteins , antibody , virology , medicine , immunology , biology , genetics , glycoprotein
We describe an antibody, made by an individual of the phenotype M+, N+, S+, s+, U+, that reacted only with ficin or papain‐treated red blood cells, and that initially appeared to have anti‐S specificity. However, further studies revealed that the antibody, which did not have anti‐U specificity, recognized a determinant present on S+, s‐, U+, and S‐, s+, U+, but missing from S‐, s‐, U‐, and S‐, s‐, U+, red blood cells. The specificity of this antibody is discussed in terms of current knowledge of the structure of the Ss sialoglycoprotein.