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Paraben‐associated autoanti‐Jk a antibodies
Author(s) -
Judd W. J.,
Steiner E. A.,
Cochran R. K.
Publication year - 1982
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1982.22182154211.x
Subject(s) - paraben , preservative , chemistry , reagent , autoantibody , chromatography , antibody , salt (chemistry) , organic chemistry , medicine , immunology
Three examples of autoantibodies with Jka specificity are reported. They all react preferentially by low‐ionic strength salt (LISS) techniques, but only in the presence of parabens (butyl, ethyl, methyl, and propyl esters of p‐hydroxybenzoate) or certain other neutral aromatic compounds. They were detected through the use of commercially prepared LISS solution containing parabens as preservatives. While it is unlikely that these autoantibodies are of clinical significance, the parabens can now be added to the list of reagent preservatives that may give rise to anomalous serologic reactions.