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Anti‐Tm is anti‐N polypeptide
Author(s) -
Issitt P.D.,
Wilkinson S.L.
Publication year - 1981
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1981.21582040809.x
Subject(s) - sialoglycoprotein , neuraminidase , antigen , chemistry , blood group antigens , sialoglycoproteins , microbiology and biotechnology , red blood cell , medicine , biochemistry , biology , immunology , glycoprotein , enzyme
Anti‐Tm defines an antigen in the MN blood group system, and 382 Tm + samples were found in tests on 900 random Caucasian, and 500 random Negro bloods. Of the 382 Tm + samples, 373 were also N +, but a further 625 N+ samples were nonreactive with anti‐Tm. We have now shown that when the original anti‐Tm serum is adsorbed free of anti‐T, and is tested against neuraminidase‐treated red blood cells, it has anti‐N specificity. Further, while anti‐Tm cannot be inhibited by sialoglycoprotein (SGP) preparations from untreated N+ red blood cells, it is inhibited by SGP fractions prepared from N+ red blood cells that have been pretreated with neuraminidase. It seems that anti‐Tm is directed against a part of the polypeptide backbone of the N SGP.