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An Analysis of Quantitative Relationships of Granulocyte Transfusion Therapy in Canines
Author(s) -
Epstein R. B.,
Chow H. S.
Publication year - 1981
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1981.21381201814.x
Subject(s) - granulocyte , medicine , cyclophosphamide , candida albicans , cerebrospinal fluid , meningitis , transfusion therapy , neutropenia , blood transfusion , immunology , chemotherapy , surgery , biology , microbiology and biotechnology
Granulocyte transfusions were administered to dogs rendered neutropenic by prior cyclophosphamide treatment. Linear regression analysis established significant direct relationships between numbers of granulocytes infused per kg body weight and blood increment achieved. Migration of granulocytes to cerebrospinal fluid during induced Candida albicans meningitis related to concurrent increments in blood following transfusion. Levels of C. albicans systemic infection were inversely related to numbers of granulocytes administered during a four‐day course of therapy. These studies demonstrate the quantitative relationships of granulocyte transfusion therapy to potential therapeutic effects at the tissue level.