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Prevention of Adverse Reactions to Blood Transfusion by the Administration of Saline‐Washed Red Blood Cells
Author(s) -
Goldfinger D.,
Lowe C.
Publication year - 1981
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1981.21381201797.x
Subject(s) - medicine , saline , incidence (geometry) , red blood cell , packed red blood cells , blood transfusion , red cell , transfusion reaction , adverse effect , whole blood , anesthesia , surgery , blood cell , significant difference , physics , optics
We prospectively compared the incidence of complications following saline‐washed versus packed red blood cell transfusions, to determine whether routine use of washed red blood cells could reduce significantly the incidence of transfusion reactions. Clinical reports of reactions were evaluated carefully to confirm whether the reaction was caused by transfusion. In 3,799 washed red blood cell transfusions, there were eight confirmed reactions (0.21%). Of 6,359 packed red blood cell transfusions, 31 reactions occurred (0.49%). The difference in incidence of confirmed complications was statistically significant (p < 0.03). Administration of washed red blood cells to all patients requiring transfusions can thus be seen to reduce significantly the incidence of adverse reactions. This is likely the result of the removal of leukocytes and plasma achieved by the washing process. The increased safety of washed red blood cells must be weighed against their extra expense to determine their cost‐effectiveness in transfusion therapy.