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Anti‐Rh41, a New Rh Antibody Found in Association with an Abnormal Expression of Chromosome 1 Genetic Markers
Author(s) -
Svoboda R. K.,
West B.,
Grumet F. C.
Publication year - 1981
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1981.21281178149.x
Subject(s) - antibody , offspring , rh blood group system , gene , chromosome , biology , microbiology and biotechnology , genetics , red blood cell , immunology , pregnancy
A new antibody, anti‐Rh41, is described. This antibody was found prepartum in a multiparous, Caucasian female with no prior history of transfusions. Anti‐Rh41 reacts with red blood cells from individuals with cis oriented C and e genes, but is nonreactive with cells possessing the products derived from individuals with cis‐oriented C w and e genes, a characteristic which distinguishes this antibody from anti‐rhi. Furthermore, in contrast to anti‐rhi, anti‐Rh41 consistently reacts with Negro rh's (VS‐positive) bloods. Also noteworthy in this study is the presence of an abnormal expression of chromosome 1 genetic markers in an offspring of the propositus.