Premium
The quality assurance of antiglobulin reactions with Fab‐sensitized reagent red blood cells
Author(s) -
Wenz B.,
Dugan E.P.
Publication year - 1981
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1981.21181127483.x
Subject(s) - reagent , chemistry , antigen , immunology , microbiology and biotechnology , medicine , biology
The production, function, and use of a new antiglobulin control cell is described. The cells are sensitized with monovalent Fab (fragment, antigen‐binding) fragments and can be agglutinated by active antiglobulin serum only. In contrast to commercial antiglobulin control cells, which are frequently associated with false‐positive results, the reactivity of the Fab‐sensitized cells is entirely specific. It is concluded that Fab‐sensitized cells provide greater quality assurance than currently available reagents.