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Viability and Function of Stored Sickle Erythrocytes
Author(s) -
Castro O.
Publication year - 1980
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1980.20681057159.x
Subject(s) - autotransfusion , sickle cell anemia , medicine , red blood cell , anemia , blood preservation , cell , physiology , immunology , disease , andrology , blood transfusion , biology , biochemistry
Functional and metabolic characteristics of fresh and three‐week stored erythrocytes from patients with sickle cell anemia were compared. The storage‐related changes in ATP, 2,3‐DPG, and P 50 in sickle erythrocytes were similar to those in control (HbA) red blood cells. After storage in CPD, sickle erythrocytes maintained significantly higher levels of 2,3‐DPG (mean 2.20 ± 0.73 mm/ml RBC) than did control cells (mean 0.36 ± 0.13 mm/ml RBC). The posttransfusion recovery and survival of stored SS erythrocytes in autologous recipients and in an animal test system were at least as good as those before storage. Tolerance of the storage lesion by sickle erythrocytes is probably related to their young mean cell age. These results also suggest that the option of autotransfusion should be explored for selected patients with sickle cell disease in special clinical settings.