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Modifications of B, I, i, and Lewis b Antigens in a Patient with DiGuglielmo's Erythroleukemia
Author(s) -
Kolins J.,
Allgood J. W.,
Burghardt D. C.,
Klein H. G.,
McGinniss M. H.
Publication year - 1980
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1980.20581034514.x
Subject(s) - abo blood group system , antigen , blood group antigens , immunology , leukemia , medicine , concomitant
Loss of red blood cell antigens has been documented in patients with acute myelocytic leukemia and includes loss of A, B and H antigens in the ABO system as well as antigens of the Rh, MNSsU, Lewis and Ii systems. The following case represents partial loss of the B, I and Lewisb antigens in a patient with erythroleukemia. Also, the loss of the I antigen was associated with a concomitant increase in i antigen, a known but rare finding. These changes within the ABO, Ii, and Lewis systems do not appear to be coincidental, as these blood group systems share a common biochemical backbone.