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pH‐Dependent Anti‐U in Autoimmune Hemolytic Anemia
Author(s) -
Bell C. A.,
Zwicker H.
Publication year - 1980
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1980.20180125047.x
Subject(s) - autoimmune hemolytic anemia , autoantibody , coombs test , medicine , immunology , serology , anemia , hemolytic anemia , jaundice , hemoglobin , hemolysis , antibody , leukemia , chronic lymphocytic leukemia , platelet , gastroenterology
Auto anti‐U of unusual serologic characteristics is described in a Caucasian patient with autoimmune hemolytic anemia associated with chronic lymphocytic leukemia. The direct antiglobulin test was strongly positive (3+) with broad spectrum and anticomplement reagents. Auto anti‐U was demonstrated only when the serum was acidified to pH 6.5 and anticomplement reagent was used in the antiglobulin test. Multiple transfusions of U positive red blood cells had clinically decreased survival manifested by jaundice and return of hemoglobin to pretransfusion levels within days. The autoantibody reacted weakly with U positive cord red blood cells interpreted as mosaicism of the U antigen possibly on a developmental basis.