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Use of In Vitro Assays in Selection of Compatible Platelet Donors
Author(s) -
Tosato G.,
Appelbaum F. R.,
Trapani R. J.,
Dowling R.,
Deisseroth A. B.
Publication year - 1980
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1980.20180125040.x
Subject(s) - in vitro , selection (genetic algorithm) , platelet , immunology , medicine , biology , genetics , computer science , artificial intelligence
Although HLA‐matched platelet transfusions are of value in the support of some alloimmunized thrombocytopenic patients, poor posttransfusion increments can be observed following HLA‐matched platelet transfusions and conversely good posttransfusion increments may result after HLA‐mismatched platelet transfusions. We have explored the possibility that in vitro assays in addition to HLA typing might better select compatible donors for refractory recipients. Our studies suggested that a platelet migration inhibition assay is predictive of platelet transfusion responses in HLA‐compatible and incompatible donor‐recipient pairs, while lymphocyto‐toxicity is predictive of posttransfusion increments only in HLA‐incompatible donor‐recipient pairs. Granulocy‐totoxicity, microleukoagglutination, and capillary leu‐koagglutination showed no value in predicting platelet transfusion increments, either in HLA‐compatible or incompatible donor‐recipient pairs.