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Failure to Confirm Specificity of Samples Containing a Very High Titer of Hepatitis B Surface Antigen (HBsAg)
Author(s) -
Nath N.,
Armbruster A.,
Ellis F. R.
Publication year - 1979
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1979.19379204215.x
Subject(s) - hbsag , titer , antigen , virology , medicine , neutralization , hepatitis b , immunology , hepatitis , antibody , hepatitis b virus , virus
Two samples repeatedly positive for HBsAg by the AusRIA II screening procedure failed to be confirmed by neutralization with anti‐HBs serum. Both samples could be effectively neutralized by the same anti‐HBs sera if diluted 1:10, 1:50 and 1:100 prior to testing. It is suggested that the inability to neutralize was due to a very high concentration of HBsAg in these samples.