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Auto‐Anti‐Kp b Associated with Weakened Antigenicity in the Kell Blood Group System: A Second Example
Author(s) -
Beck M. L.,
Marsh W. L.,
Pierce S. R.,
DiNapoli J.,
ØYen R.,
Nichols M. E.
Publication year - 1979
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1979.19279160294.x
Subject(s) - antigenicity , antigen , chemistry , immunology , medicine
An 84‐year‐old woman with intestinal bleeding had marked reduction of red blood cell antigenicity in the Kell system, and a positive direct antiglobulin test caused by auto‐anti‐Kp b . Kx antigen activity of her cells was increased, an observation which supports the belief that Kx marks a precursor structure utilized in the normal Kell biosynthetic pathway. It is postulated that reduced Kell antigenicity was an acquired change that resulted from enzymatic degradation, possibly of bacterial origin.