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Lack of Predictive Value of Antileukocyte Antibody Screening in Granulocyte Transfusion Therapy
Author(s) -
Ungerleider R. S.,
Appelbaum F. R.,
Trapani R. J.,
Deisseroth A. B.
Publication year - 1979
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1979.19179160275.x
Subject(s) - medicine , antibody , granulocyte , incidence (geometry) , predictive value , immunology , transfusion therapy , blood transfusion , physics , optics
To clarify the relationship between recipient presen‐sitization and response to granulocyte (PMN) transfusion, we tested 187 non‐HL‐A matched donor‐recipient pairs for the presence of antileukocyte antibody using granulocytotoxicity (G), lymphocytotoxicity (L), micro‐leukoagglutination (M), and capillary leukoagglutination (C) assays. PMN increments per 10 11 transfused PMNs per square meter of body surface area, ascertained one hour following termination of transfusion, and the occurrence of nonhemolytic transfusion reactions, were correlated with the assay results. Although circulating anti‐donor‐leukocyte antibody was detected in 52 per cent of recipients, there was no statistically significant relationship between the presence of these antibodies and either PMN recovery or incidence of transfusion reaction. We conclude that the prospective use of these assays is of little value in predicting the recipient's response to PMN transfusion.