Premium
Nonhemolytic IgG Anti‐I T
Author(s) -
Hafleigh E. B.,
Wells R. F.,
Grumet F. C.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18579036393.x
Subject(s) - antibody , autoantibody , immunology , serology , medicine , hematocrit , papain , coombs test , reticulocyte , red cell , albumin , red blood cell , chemistry , enzyme , biochemistry , messenger rna , gene
Nonhemolytic, IgG, anti‐I T autoantibodies were found in the sera of three Caucasian patients, none of whom had Hodgkin's disease. Each antibody reacted by indirect antiglobulin test. Two of the three also reacted in albumin at 37 C, and one of these was moderately enhanced by papain. As judged by transfusion responses, reticulocyte counts, hematocrit stability, and one hour 51 Cr red blood cell survivals, none of the antibodies were considered to be hemolytic. When tested with anti‐IgG serum, cells from all three had a positive direct antiglobulin test. Anti‐I T antibody was eluted from their cells. Ii status of the patients' cells differed from normal in each case. These data suggest greater variation in the disease association, serologic reactivity, and clinical significance of anti‐I T than has been evident from previous studies.