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Further Studies on the Relationship of Anti‐En a and Anti‐Wr b in Warm Autoimmune Hemolytic Anemia
Author(s) -
Bell C. A.,
Zwicker H.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18579036389.x
Subject(s) - autoimmune hemolytic anemia , autoantibody , anemia , sialic acid , red blood cell , hemolytic anemia , immunology , red cell , medicine , chemistry , antibody , biochemistry
The red blood cell eluates of two patients with warm autoimmune hemolytic anemia (AIHA) were found to have anti‐dl and anti‐Wr b in a study of 150 individuals with positive AHG tests. 7 In that series 39 per cent of AIHA cases had anti‐Wr b as part of the autoantibody specificity. The eluates of these two patients were of further interest since they showed weaker reactions with En(a–) cells than with En(a+), Wr(a+b–) cells. Further absorption of the eluates confirmed a second component that reacted with the En(a+), Wr(b–) cells but not the En(a–) cell, interpreted as autoanti‐En a . In one of the cases anti‐En a was recovered from the En(a–) absorbing cell although these cells were not agglutinated by the autoantibody. This effect was not due to polyagglutinability, the Matuhasi‐Ogata phenomenon or the decreased sialic acid content of the En(a–) red blood cell membranes and remains unexplained.