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Difficulty in LW Typing as Revealed by a Family Study
Author(s) -
Behzad O.,
Pothiawala M.,
Rolih S. D.,
Issitt P. D.,
Lee C. L.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18478251248.x
Subject(s) - typing , genotype , phenotype , genetics , blood typing , biology , medicine , immunology , gene
A family is described in which two members of the second generation are of the phenotype LW 3 . In the course of the investigation the mother of the LW 3 propositus was at first believed to be phenotypically LW 3 as well. Eventually, it was shown that she is, in fact, phenotypically LW 2 but that her R −1 ( no D ), LWlw , genotype had resulted in less LW being present on her red blood cells than is expected in LW 2 persons. This reduced level of LW could not be detected with one example of anti‐LW made by an LW 3 individual.