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Anti‐Le a as an Autoantibody in the Serum of a Le (a – b+) Individual
Author(s) -
Judd W. J.,
Steiner E. A.,
Friedman B. A.,
Oberman H. A.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18478251237.x
Subject(s) - autoantibody , saliva , immunology , antibody , antigen , b cell , medicine , microbiology and biotechnology , biology
The first example of anti‐Le a , as an autoantibody, in the serum of a phenotypically Le (a–b+) individual is described. The patient is a 55 year old male with squamous cell carcinoma of the esophagus. His saliva contains Le a , Le b and H substances, and inhibits the hemagglutinating activity of his serum anti‐Le a . The Le b antigen content of his red blood cells is approximately half that of control Le (a–b+) red blood cells. The patient's disease process may be responsible for the development of this unexpected autoantibody.