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Blood Preservation XXVII. Fructose and Mannose Maintain ATP and 2,3‐DPG
Author(s) -
Dawson R. B.,
Levine Z.,
Zuck T.,
Hershey R. T.,
Myers C.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18378205145.x
Subject(s) - mannose , fructose , chemistry , biochemistry , medicine
Mannose and fructose as well as glucose have been shown to be effective for maintaining ATP and thus viability of stored red blood cells. Normal 2,3‐DPG levels are desirable in stored red blood cells to provide the needed oxygen transport upon transfusion. ATP levels in stored concentrated red blood cells in the new preservative, CPD‐adenine (citrate‐phosphate‐dextrose‐adenine) become critically low in the 5th week. In this study two hexoses and two pentoses are compared with dextrose in their ability to maintain ATP and 2,3‐DPG. ATP levels were best maintained by fructose, then dextrose and mannose. ATP levels had fallen to critically low levels by four weeks with ribose and xylose. Red blood cell 2,3‐DPG concentrations were also maintained by hexoses, with mannose being best, dextrose and fructose being similar. When ribose was used in addition to dextrose in CPD‐adenine, ATP maintenance was improved and under the same conditions xylose improved 2,3‐DPG maintenance. Fructose and mannose may be as useful as dextrose in citrate‐phosphate preservatives for maintaining ATP and 2,3‐DPG levels. Also, ribose and xylose may help the maintenance of ATP and 2,3‐DPG, respectively, in CPD‐adenine.