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Matuhasi‐Ogata Phenomenon Involving Anti‐Ampicillin
Author(s) -
Bell C. A.,
Zwicker H.,
Whitcomb M.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18278160593.x
Subject(s) - ampicillin , antibody , chronic pyelonephritis , medicine , drug , red blood cell , red cell , antigen , immunology , pharmacology , microbiology and biotechnology , biology , antibiotics
A 47‐year‐old group A, Rh 1 Rh 1 woman treated with intravenous ampicillin for chronic pyelonephritis received two units of blood and also received oral cephalexin. Three months after the transfusions she was noted to have allo‐anti‐E and anti‐c, and a 2 + positive direct antiglobulin test. Anti‐E and anti‐c could be eluted from her cells, yet neither antigen could be demonstrated on the patient's circulating red blood cells. Also present in the serum and in the eluate was anti‐ampicillin antibody. Studies of the patient's red blood cell eluates using ampicillin‐treated R 1 R 1 and untreated R 2 R 2 cells demonstrated anti‐E complexed with anti‐ampicillin in a drug‐related example of the Matuhasi‐Ogata phenomenon. Artificially created mixtures of anti‐E and drug antibody could reproduce the effect in vitro. No effect of cephalexin could be demonstrated. The variability of the Matuhasi‐Ogata phenomenon is discussed with regard to the sequence of antibody attachment, and the possible relationship to cephalexin is discussed. Drug antibodies may be involved in the Matuhasi‐Ogata phenomenon in cases where another red blood cell antibody cannot be shown to be present.