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Procainamide‐induced Hemolytic Anemia
Author(s) -
Jones G. W.,
George T. L.,
Bradley R. D.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18278160589.x
Subject(s) - procainamide , hemolytic anemia , anemia , medicine , immunology
The paper reports a case of hemolytic anemia induced by procainamide hydrochloride treatment. Decreases in hemoglobin concentration are correlated with 11 months of procainamide treatment along with a marked increase in hemoglobin following cessation of the drug. The paé tient exhibited no symptoms suggestive of drug‐induced Lupus Erythematosus that has been frequently reported as a sequela of procainamide therapy. Direct antiglobulin tests were consistently positive throughout the clinical course, and an ether‐eluate prepared from the patient's red blood cells showed panagglutinability. The antibody in the eluate reacted with Rh null , D–, LW negative, and U negative red blood cells without addition of proé cainamide or pretreatment of red blood cells with the drug. It is noted that this antibody reacts similarly to the antibody produced as a consequence of alpha‐methyldopa therapy.