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A Study on the Erythrocyte Aggregating Properties of Polybrene and Protamine Sulphate
Author(s) -
Inglis G.,
Sheridan R.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18178118572.x
Subject(s) - protamine , protamine sulfate , sialic acid , chemistry , receptor , biochemistry , biophysics , biology , heparin
By observing the aggregation of erythrocytes in protamine sulphate or Polybrene it is possible to predict MN phenotypes with 97 per cent accuracy. It is probable that one factor influencing aggregation is the relative site density of a receptor common to both M and N antigen structures although other nondiscriminating receptor sites on a lower layer of sialic acid are possibly also involved.