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Effects of Fenwal 4C2423 Transfusion Microfilter on Microaggregates and Other Constituents of Stored Blood
Author(s) -
Marshall B. E.,
Wurzel H. A.,
Neufeld G. R.,
Aukburg S. J.,
Ewing B. C.,
Fried R. J.,
Barnes C.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18178118564.x
Subject(s) - hemoglobin , coulter counter , hemolysis , albumin , red blood cell , chemistry , zoology , medicine , biology , biochemistry , microbiology and biotechnology
The effects of a new micropore transfusion filter (Fenwal 4C2423) on stored whole blood have been examined. Five filters were preloaded by passage of two units of outdated type specific bank blood, and the effects of filtration on a third unit, consisting of 21‐day‐old blood, flowing under 150 mmHg pressure, were measured. Filtration did not significantly alter red blood cell count, total hemoglobin, red blood cell fragility, plasma sodium, potassium, albumin, or globulin. Some platelets and white blood cells were removed and a small amount of hemolysis of erythrocytes (<0.1%) was observed. Removal of microaggregates, assessed by Coulter counting, screen filtration pressure, total screen proteins, wet and dry weights of material retained, and scanning electron microscopy, was shown to be excellent over the entire range of particle size. Comparison of the Bentley PFS‐127, Fenwal 4C2417, Johnson & Johnson Intersept®, Pall Ultipore®, and Swank IL200 filters led to the conclusion that the Fenwal 4C2423 was both a significant improvement over the previous Fenwal design and comparable to the most efficient of these filters for both the removal of microaggregates during massive blood transfusion and for the blood flow rates obtained.