Premium
An Investigation of the Relationship between the V(hr v ), VS, and hr H Antigens
Author(s) -
Tregellas W. M.,
Issitt P. D.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1978.18178118561.x
Subject(s) - antigen , antiserum , absorption (acoustics) , antibody , chemistry , red blood cell , microbiology and biotechnology , immunology , medicine , endocrinology , biochemistry , biology , physics , acoustics
The data from this investigation show that the anti‐VS sera studied cannot be separated into anti‐hr v (anti‐V) and anti‐hr H specificities. The antibody specificity is singular and is directed against an antigenic determinant present on VS positive red blood cells. That some anti‐VS sera appear to have a separable specificity may be due to the incomplete absorption of those antisera. It was shown that V–, VS+ red blood cells adsorb more anti‐VS than do those that are V+, VS+. Several absorption of anti‐VS serum with V +, VS + red blood cells may remove enough of the antibody that the absorbed serum will no longer (visibly) react with V +, VS+ red blood cells, though the same absorbed serum will react with V‐, VS+ red blood cells. That this is not a separable specificity can be demonstrated by subsequent absorption to exhaustion of the same serum with V +, VS+ red blood cells. Testing of the original Hernandez serum confirmed that it defines the antigenic specificity, hr H . The relationship of hr H to VS may be similar to the relationship of the Rh o (D) antigen to the antigens of the Rh o (D) mosaic.