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Fetal Cell Counting as an Evaluation of Rh Prophylaxis with Antenatally Administered Anti‐Rh O (D) Gamma Globulin
Author(s) -
Harrison K. L.
Publication year - 1977
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1977.17678075667.x
Subject(s) - fetus , gestation , rh blood group system , medicine , gamma globulin , rh isoimmunization , abo blood group system , andrology , obstetrics , pregnancy , antibody , immunology , biology , genetics
Fetal cell counts were performed on pregnant women at 34 weeks' gestation following an injection of Anti‐Rh o (D) gamma globulin at 28 weeks' gestation. In cases where the fetus subsequently proved to be Rh o (D) positive and ABO compatible, the fetal cell detection rate and the mean number detected were considerably less than those where the fetus was Rh negative. Postpartum fetal cell counts after one and two antenatal anti‐Rh o (D) gamma globulin injections were also less when the baby was Rh positive than when the baby was Rh negative. These findings provide evidence that antigen clearance is definitely part of the mechanism involved in Rh prophylaxis by the use of anti‐Rh o (D) gamma globulin.