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Occurrence of Anti‐Wr a in Blood Donors and in Selected Patient Groups, with a Note on the Incidence of the Wr a Antigen
Author(s) -
Greendyke R. M.,
Banzhaf J. C.
Publication year - 1977
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1977.17678075661.x
Subject(s) - incidence (geometry) , medicine , antigen , pediatrics , immunology , physics , optics
The occurrence of the Wr a antigen on the red blood cells of 5,000 primarily Caucasian New York State blood donors was shown to be 1:1,000. Anti‐Wr a was detected in sera from random blood donors with a frequency of 1:56 and with progressively increasing frequency in postpartum women, patients undergoing open‐heart surgery, hemodialysis subjects, and random persons with other alloantibodies. Anti‐Wr a was found in one fourth of sera from patients with positive direct antiglobulin tests, including 12 of 23 in whom the positive test was associated with alphamethyldopa treatment.