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Formaldehyde in the Pathogenesis of Hemodialysis‐related Anti‐N Antibodies
Author(s) -
White W. L.,
Miller G. E.,
Kaehny W. D.
Publication year - 1977
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1977.17578014581.x
Subject(s) - pathogenesis , antibody , formaldehyde , hemodialysis , in vitro , antigen , sialic acid , chemistry , dialysis , immunology , medicine , biochemistry
The role of formaldehyde (CH 2 O) in the pathogenesis of anti‐N‐like antibodies found in patients on chronic hemodialysis was investigated. In vitro studies were performed by incubating MM cells in varying concentrations of CH 2 O for variable time periods, corresponding to conditions that occur in dialysis. These MM cells acquired reactivity to anti‐N antibody. The antigenic shift is felt to occur from the interaction of CH 2 O) with the terminal N‐acetylneuraminic acid (sialic acid) groups of M substance, resulting in the exposure of an altered‐N antigen that is immunogenically active. Through a similar mechanism, CH 2 O may also directly modify N substance.