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Plasma exchange for cold agglutinin hemolytic anemia
Author(s) -
Taft Edwin G.,
Propp Richard P.,
Sullivan Susan A.
Publication year - 1977
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1977.17277151925.x
Subject(s) - cold agglutinin , medicine , anemia , exchange transfusion , autoimmune hemolytic anemia , hemolytic anemia , cold agglutinin disease , red cell , refractory (planetary science) , lymphoma , surgery , gastroenterology , immunology , antibody , physics , astrobiology
Two patients with advanced lymphoma, chronic cold agglutinin disease refractory to conventional therapy and severe, progressive anemia were treated with exchange plasma transfusion. Both experienced significant reduction in titers. The first patient, in whom the procedure was done manually, died with widespread lymphoma without achieving apparent clinical benefit. The second patient was exchanged using the Aminco Celltrifuge, with improvement in in vitro compatibility tests and transfusion tolerance. The technical details of continuous‐flow centrifugation exchange plasma transfusion are described.