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Use of dextran 75 as a macromolecular agent in centrifugal leukapheresis
Author(s) -
Huestis DW
Publication year - 1977
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1977.17277151921.x
Subject(s) - leukapheresis , hydroxyethyl starch , premedication , dextran , granulocyte , saline , medicine , anesthesia , surgery , chemistry , chromatography , biology , genetics , stem cell , cd34
Twenty‐five leukaphereses were done by the Haemonetics system using citrated Dextran 75 in normal saline as anticoagulant, and were compared with a much larger series using hydroxyethyl starch (HES) with and without steroid premedication. The granulocyte and platelet yields were only minimally different between the two agents. Both were inferior in granulocyte collection to the group that was premedicated with a steroid. Dextran is thus a satisfactory substitute for HES in leukapheresis with this system.