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In Vivo Stability of Cryoprecipitate Fibrinogen
Author(s) -
Sherman L. A.
Publication year - 1977
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1977.17177128887.x
Subject(s) - cryoprecipitate , fibrinogen , clearance , in vivo , medicine , pharmacology , urology , biology , microbiology and biotechnology
Because of its lower hepatitis risk, cryoprecipitate has been advocated as a substitute for commercial fibrinogen. Previous literature on cryofibrinogen has demonstrated a short blood t t 1/2. rendering it unsuitable for therapeutic/ use. The in vivo clearance of 131 I‐cryoprecipitate was compared with that of 125 I‐standard fibrinogen. A small amount of cryoprecipitate was rapidly cleared and apparently was cryofibrinogen. However, the bulk of the cryoprecipitate was cleared with a normal half life, as was cryoprecipitate that was in 10‐bag pools. The data indicated cryoprecipitate was an effective in vivo form of fibrinogen and thus the preferred fibrinogen source because of its combining normal t 1/2 with single donor procurement.