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Viability of Granulocytes Obtained by Filtration Leukapheresis
Author(s) -
Roy A. J.,
Yankee R. A.,
Brivkalns A.,
Fitch M.
Publication year - 1975
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1975.15676082228.x
Subject(s) - pentose phosphate pathway , leukapheresis , hexose , chemistry , granulocyte , pentose , filtration (mathematics) , biochemistry , microbiology and biotechnology , metabolism , biology , glycolysis , immunology , enzyme , statistics , mathematics , stem cell , cd34 , fermentation
Nylon filtration alters the morphology of human granulocytes and slightly reduces their phagocytic ability as measured by activation of the hexose monophosphate shunt (HMS) pathway of glucose metabolism. In addition, the ability of rat granulocytes to circulate in granulocytopenic rats is reduced, and this is not attributed to HMS activation during filtration. The activation of the hexose monophosphate shunt is related to the size of the particles rather than to the nature of the material.