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A New Example of Anti‐LW and Further Studies on Heterogeneity of the System
Author(s) -
White J. C.,
Rolih S.,
Wilkinson S. L.,
Hatcher B. J.,
Issitt P. D.
Publication year - 1975
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1975.15476034561.x
Subject(s) - blood group antigens , antigen , false positive paradox , red cell , red blood cell , biology , microbiology and biotechnology , medicine , genetics , immunology , mathematics , statistics
A case is reported in which an LW, woman formed anti‐LW. It is shown that the case represents the “genetic” and not the “transient” type of red blood cell LW antigen depletion. Studies have confirmed the quantitative difference of LW antigen on LW 3 and LW 4 red blood cells and the fact that Rh null individuals produce the only totally LW‐negative red blood cells. The difficulties encountered in the identification of anti‐LW, because of the LW 3 and LW, states, are described. It is clear, from this study, that if random donors are typed for LW using anti‐LW made by an LW 4 individual, those who are LW 3 will be classed as unremarkable LW‐positives.