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An Autoantibody with Anti‐Wr b Specificity in a Patient with Warm Autoimmune Hemolytic Anemia
Author(s) -
Goldfinger D.,
Zwicker H.,
Belkin G. A.,
Issitt P. D.
Publication year - 1975
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1975.15476034556.x
Subject(s) - autoantibody , autoimmune hemolytic anemia , medicine , immunology , anemia , pathogenesis , disease , pathology , antibody
A patient with warm autoimmune hemolytic anemia (AIHA) has been found to possess an autoantibody with Wr b specificity. While this is the first known description of Wr b specificity in this disease, additional studies on the Wr b status of En(a‐) cells indicate that autoantibodies previously thought to be anti‐En a are in reality also anti‐Wr b . Autoantibodies with Wr b specificity may thus be a rather common finding in patients with AIHA who have been thought to have “panagglutinins” on their red blood cells. Since anti‐Wr a alloantibodies are found frequently in patients with AIHA, it seems possible that the Wright system holds some clue to the pathogenesis of this disease.