Observations on the Gy a  and Hy Antigens and the Antibodies that Define Them | Zendy

Moulds J. J. | Zendy; Polesky H. F. | Zendy; Reid M. | Zendy; Ellisor S. S. | Zendy

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Observations on the Gy a and Hy Antigens and the Antibodies that Define Them

Author(s) -

Moulds J. J.,

Polesky H. F.,

Reid M.,

Ellisor S. S.

Publication year - 1975

Publication title -

transfusion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.045

H-Index - 132

eISSN - 1537-2995

pISSN - 0041-1132

DOI - 10.1046/j.1537-2995.1975.15375160364.x

Subject(s) - avidity , antibody , antigen , titer , immunology , medicine , biology

Two high frequency antigens, Hy (Holley) and Gy a (Gregory), show an apparent association. All individuals lacking Gy a are whites and these individuals are Hynegative. A second group of Hy‐negative individuals are blacks. All of these react weakly with anti‐Gy a . Neither Gy a nor Hy are well developed on cord cells, although antibodies to both factors have been stimulated by pregnancy. Anti‐Gy a and anti‐Hy antibodies react best in the antihuman globulin test. These antibodies have low avidity, high titers, and have been implicated as causing transfusion reactions.

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