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Some Observations on “Bombay” Bloods, with Comments on Evidence for the Existence of Two Different O h Phenotypes
Author(s) -
Moores P. P.,
Issitt P. D.,
Pavone B. G.,
McKeever B. G.
Publication year - 1975
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1975.15375160358.x
Subject(s) - abo blood group system , antibody , antigen , titer , phenotype , isoantibodies , chemistry , h antigen , red blood cell , microbiology and biotechnology , rh blood group system , immunology , biology , biochemistry , gene
Bloods from three individuals, one each of the phenotypes O h A , O h B and O h O have been studied. The work of Dzierzkowa‐Borodej, et al. 10 was confirmed when it was shown that all three samples of O h red blood cells had increased I antigen strength. The i, Sd a , Le a and Le x antigens were not found to be increased. Attempts were made to adsorb and elute anti‐A, anti‐B and anti‐A, B with the O h red blood cells, using sera that contained high titered anti‐I antibodies. This was done in the belief that previously reported positive results in such tests might be due to the high level of I on the O h red blood cells, anti‐I in the sera containing the ABO antibodies, and the Matuhasi‐Ogata phenomenon. However, in no instance were we able to adsorb an ABO antibody onto the O h red blood cells. Contrary to the report of others 10 the titers of anti‐A, anti‐B and anti‐H in the sera of the three O h individuals studied did not differ significantly. We suggest that the evidence from our findings and the work of others is sufficient to show that at least two forms of the O h phenotype exist: one representing total suppression of H, A, and B antigens, and the other marked but not total suppression, with partial inhibition of antibody production.