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The analgesic effect of codeine as compared to imipramine in different human experimental pain models. (University of Southern Denmark, Odense, Denmark) Pain. 2001;92:277–282.
Author(s) -
Enggaard Thomas P.,
Poulsen Lars,
ArndtNielsen Lars,
Hansen Steen Honoré,
Bjørnsdottir Inga,
Gram Lars F.,
Sindrup Søren H.
Publication year - 2001
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1046/j.1533-2500.2001.1039_44.x
Subject(s) - medicine , anesthesia , analgesic , codeine , summation , placebo , imipramine , stimulation , neuropathic pain , pain tolerance , sural nerve , threshold of pain , morphine , surgery , pathology , alternative medicine
The hypoalgesic effect of single oral does of 100 mg imipramine and 125 mg codeineWas evaluated in this randomized, placebo‐controlled experiment that included 18 healthy volunteers. Pain tests were performed before and 90, 180, 270, 360, and 450 min after medication. The tests included determination of pain tolerance thresholds to pressure, single electrical sural nerve stimulation, and to repetitive sural nerve stimulation. Codeine significantly increased pressure pain tolerance, pain detection and pain tolerance thresholds. It was concluded that both imipramine and codeine inhibit temporal pain summation, whereas only codeine reduces cold pressor pain. Pain summation may be a key mechanism in neuropathic pain. Imipramine has a documented effect on such pain conditions on temporal summation. In addition, this study showed that codeine also inhibits temporal summation, which is in line with the clinical observations indicating that opioids relieve neuropathic pain.