Premium
The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats. (Massachusetts General Hospital, Charlestown, MA) Anesth Analg 2000;91:955–959.
Author(s) -
Abdi Salahadin,
Vilassova Natalia,
Decosterd Isabelle,
Feroz Nusrat,
Borsook David
Publication year - 2001
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1046/j.1533-2500.2001.01023-7.x
Subject(s) - neuropathic pain , medicine , nociception , allodynia , anesthesia , hyperalgesia , receptor
This study investigated the effects of a spicamycin derivative, KRN5500, on two models of neuropathic pain (Chung and Bennett models) and a nociceptive pain model by using Complete Freund's adjuvant. After the establishment of mechanical models, a single intraperitoneal injection of KRN5500 produced significant attenuation of mechanical allodynia in both neuropathic pain models. However, this effect was not observed in rats that had a nociceptive injury. Furthermore, this experimental drug did not alter the mechanical pain threshold on normal, uninjured rats. Conclude that the KRN5500 may have value in the treatment of neuropathic pain.