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Pain mechanisms and management: a central perspective. (Massachusetts General Hospital, Charlestown, MA) Clin J Pain 2000;16:S144–S156.
Author(s) -
Mannion Richard J.,
Woolf Clifford J.
Publication year - 2001
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1046/j.1533-2500.2001.01023-36.x
Subject(s) - medicine , nociception , spinal cord , neuroscience , perspective (graphical) , neuroplasticity , dorsum , central sensitization , chronic pain , french horn , spinal cord injury , anesthesia , physical therapy , anatomy , psychiatry , psychology , receptor , pedagogy , artificial intelligence , computer science
This article reviews the specific role of the dorsal horn of the spinal cord in the mechanisms of nociceptive protective pain and the spinal plasticity that occurs after nerve and tissue injury. Spinal neuronal plasticity is shown to be a key contributor to pathologic pain hypersensitivity. The potential for the molecular mechanisms responsible for the spinal plasticity in revealing new targets for future treatment is also discussed.